Cameron M. Sills
Research: Human cytomegalovirus (HCMV) is both the leading infectious cause of birth defects in newborns and a major pathogen affecting those with suppressed immune systems, for example, transplant patients. HCMV displays a particularly broad tropism for human cells, and is thought to accomplish this in part by altering the composition of viral glycoprotein complexes on the virion surface which are involved in cell entry. I am investigating the role of an HCMV encoded ER resident glycoprotein, UL148, in the regulation of the ratios of these alternative viral glycoprotein complexes and its involvement in cell tropism.
Supported by a grant from the National Institute of General Medical Sciences (P30-GM110703).