B.S., Biology, 2014, University of Houston
Research: Our lab has focused on understanding how Human Cytomegalovirus (HCMV) infection of monocytes promotes viral spread. We have demonstrated that binding of viral glycoproteins to cellular epidermal growth factor receptor (EGFR) and integrins drives a unique signalosome in monocytes, which initiates biological changes required for hematogenous dissemination. This signalosome facilitates viral entry and nuclear translocation in monocytes. My project seeks to determine how HCMV-induced signaling through EGFR and integrins directs viral trafficking to the nucleus of the infected monocyte.