Kellie N. Brown
B.S., Biology, 2015, University of Memphis
Research: Rotavirus causes gastroenteritis that can be life-threatening in children. The rotavirus nonstructural protein NSP1 inhibits the host immune response by promoting the degradation of proteins required for interferon production. NSP1 has been shown to interact with cullin RING ligases (CRLs), which are host ubiquitin ligase complexes. My research is investigating the NSP1-CRL interaction to determine if NSP1 is using this complex to induce degradation of host proteins or if the interaction has other roles in viral replication.