Office Phone: 318-675-6263
Laboratory Phone: 318-675-4180
Office Fax: 318-675-5764
Mechanisms for Epstein-Barr virus-mediated tumor progression
Epstein-Barr virus (EBV) is a prevalent herpesvirus that infects greater than 95% of the world’s adult population, usually without consequence. However, in some cases, the virus is associated with the development of lymphoid and epithelial malignancies. The long-term goal of our laboratory is to delineate mechanisms by which EBV mediates tumor progression. Two major areas are currently being investigated. The first research area involves understanding how epigenetic alterations on the virus and host genome that contribute to tumorigenesis. The second area involves understanding interactions between Epstein-Barr virus and human papillomavirus in oral cancer.
Moody CA, Scott RS, Su T, Sixbey JW. 2003. Length of Epstein-Barr Virus termini as a determinant of epithelial cell clonal emergence. J Virol.; 77: 8555-61. PMCID: PMC165260
Scott R S, Moody CA, and Sixbey JW. 2005. Epstein-Barr virus and oral malignancies. In: Robertson E (ed). Epstein-Barr virus: Pathogenesis, Molecular Biology, and Infection. Horizon Scientific Press/Caister Academic Press, Norfolk, U.K.
Jiang R, Scott RS, and Hutt-Fletcher L. 2006. Epstein-Barr virus shed in saliva is high in B-cell-tropic glycoprotein gp42. J Virol. 80(14): 7281-7283. PMCID: PMC1489022
Ikuta K, Srinivas SK, Schacker T, Miyagi JI. Scott RS, Sixbey JW. 2008. Points of Recombination in P3HR-1-Derived Heterogeneous (het) DNA as an Index to EBV DNA Recombinogenic Events In Vivo. J Virol. 82(23):11516-25. PMCID: PMC2583645
Repic AM, Scott RS, Shi M, Sixbey JW. 2010. Augmented LMP1 Expression from Epstein-Barr Virus (EBV) Episomes with Minimal Terminal Repeats. J. Virol. 84(5):2236-44. PMCID: PMC2820940
Ikuta K., Ding M, Zhang F, Sixbey JW, and Scott RS. 2011. Epithelial Cell Retention of Transcriptionally Active, P3HR1-Derived Heterogeneous (het) EBV DNA with Concurrent Loss of Parental Virus. J Virol. 85(15): 7634-7543. PMCID: PMC3147926
Queen KJ, Shi M, Zhang F, Cvek U and Scott RS. 2013. Epstein–Barr virus-induced epigenetic alterations following transient infection. Int. J. Cancer. 132(9):2076-86. PMCID: PMC3578144
Shi M, Davis TO, Gan Y, and Scott RS. 2013. Downregulation of a polyamine regulator, spermidine/spermine N1-acetyltransferase (SSAT), by Epstein-Barr virus in a Burkitt’s Lymphoma Cell Line. Virus Res. 2013 Oct;177(1):11-21. PMID: 23891576
Birdwell CE, Queen KJ, Rollyson P, Kilgore P, Trutschl M, Cvek U, Scott RS. 2014. Genome-wide DNA methylation as an epigenetic consequence of Epstein-Barr virus infection of immortalized keratinocytes. J Virol. 88(19):11442-58. PMCID: PMC4178815
Trutschl M, Kilgore PCSR, Scott RS, Birdwell CE and Cvek U. 2014. Detection and Employment of Biological Sequence Motifs. In Big Data Analytics in Bioinformatics and Healthcare. IGI Global. 86-116.
Jiang R, Ekshyyan O, Moore-Medlin T, Rong X , Nathan S, Gu X, Abreo F, Rosenthal EL, Shi M, Guidry JT, Scott RS, Hutt-Fletcher LM, Nathan CO. 2015. Association between HPV/EBV co-infection and oral carcinogenesis. J Oral Pathol Med. 44(1):28-36. PMCID: PMC4286485
All Publications: Pubmed